Frontiers in Oral Health, Oral Surgery
Dedicated issue: Medication Related Osteonecrosis of the Jaw.
Guest Editors: Josiah Eyeson, Vinod Patel and Ourania Nicolatou-Galitis
It is my great honour to be a part of the Guest Editors Team in the Frontiers Oral Health, Oral Surgery section, dedicated to
Medication Related Osteonecrosis of the Jaw
Osteonecrosis of the Jaw was first reported by Marx in 2003 as a side effect of the administration of the bisphosphonates, Pamidronate and Zoledronic acid, as part of treatment for bone metastasis. This condition was named bisphosphonate related osteonecrosis of the jaw (MRONJ). Over time, other drugs, such as the anti-receptor activator of nuclear kappa-B ligand (RANKL) antibody Denosumab, angiogenic inhibitor Bevacizumab, and other targeted therapies, including immunotherapy, without antiresorptive properties, have been associated with development of jaw osteonecrosis. Subsequently, the condition was renamed Medication Related Osteonecrosis of the Jaw (MRONJ).
A variety of conditions, including Paget’s disease, osteogenesis imperfecta, osteoporosis, multiple myeloma, and metastatic bone disease of solid tumours e.g. breast cancer, are treated with these drugs. This series aims to provide an update on the pathogenesis of MRONJ, drugs associated with MRONJ, strategies to reduce risk of MRONJ, and current management strategies for MRONJ.
This Research Topic aims to:
- Provide an updated overview of drugs associated with MRONJ development and their mechanism of action,
- Discuss the pathogenesis for the development of MRONJ,
- Review reported patient risk assessment strategies to mitigate or prevent development of MRONJ,
- Review management strategies for MRONJ.
We welcome topic articles related to the following themes:
- Update on Drugs associated with MRONJ and their pharmacology – Interested in a comprehensive review,
- Discuss Pathogenesis for the development of MRONJ – original research manuscript, comprehensive review,
- Review Patient risk assessment and prevention strategies for MRONJ – original research manuscript, systematic review,
- Discuss Management strategies for MRONJ – original research manuscript, systematic review.
In behalf of the Guest Editors: Josiah Eyeson, Vinod Patel and Ourania Nicolatou-Galitis